Influence of Bacterial Culture Medium on Peptidoglycan Binding of Cell Wall Lytic Enzymes

Influence of Bacterial Culture Medium on Peptidoglycan Binding of Cell Wall Lytic Enzymes

The bacteriolysin lysostaphin (Lst) and endolysin PlyPH are potent modular lytic enzymes with exercise in opposition to clinically-relevant Gram-positive Staphylococcus aureus and Bacillus cereus, respectively. Both enzymes possess an N-terminal catalytic area and C-terminal binding area, with the latter conferring important enzyme specificity. Lst and PlyPH present diminished exercise within the presence of bacterial growth-supporting …

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